Jawbone microenvironment promotes periodontium regeneration by regulating the function of periodontal ligament stem cells
Identifieur interne : 000191 ( Main/Exploration ); précédent : 000190; suivant : 000192Jawbone microenvironment promotes periodontium regeneration by regulating the function of periodontal ligament stem cells
Auteurs : Bin Zhu [République populaire de Chine] ; Wenjia Liu [République populaire de Chine] ; Yihan Liu [République populaire de Chine] ; Xicong Zhao [République populaire de Chine] ; Hao Zhang [République populaire de Chine] ; Zhuojing Luo [République populaire de Chine] ; Yan Jin [République populaire de Chine]Source :
- Scientific Reports [ 2045-2322 ] ; 2017.
Abstract
During tooth development, the jawbone interacts with dental germ and provides the development microenvironment. Jawbone-derived mesenchymal stem cells (JBMSCs) maintain this microenvironment for root and periodontium development. However, the effect of the jawbone microenvironment on periodontium tissue regeneration is largely elusive. Our previous study showed that cell aggregates (CAs) of bone marrow mesenchymal stem cells promoted periodontium regeneration on the treated dentin scaffold. Here, we found that JBMSCs enhanced not only the osteogenic differentiation of periodontal ligament stem cells (PDLSCs) but also their adhesion to titanium (Ti) material surface. Importantly, the compound CAs of PDLSCs and JBMSCs regenerated periodontal ligament-like fibers and mineralized matrix on the Ti scaffold surface, both in nude mice ectopic and minipig orthotopic transplantations. Our data revealed that an effective regenerative microenvironment, reconstructed by JBMSCs, promoted periodontium regeneration by regulating PDLSCs function on the Ti material.
Url:
DOI: 10.1038/srep40088
PubMed: 28053317
PubMed Central: 5215380
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000840
- to stream Pmc, to step Curation: 000840
- to stream Pmc, to step Checkpoint: 000174
- to stream Ncbi, to step Merge: 006D31
- to stream Ncbi, to step Curation: 006D31
- to stream Ncbi, to step Checkpoint: 006D31
- to stream Main, to step Merge: 000191
- to stream Main, to step Curation: 000191
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Jawbone microenvironment promotes periodontium regeneration by regulating the function of periodontal ligament stem cells</title><author><name sortKey="Zhu, Bin" sort="Zhu, Bin" uniqKey="Zhu B" first="Bin" last="Zhu">Bin Zhu</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>State Key Laboratory of Military Stomatology, Centre for Tissue Engineering, School of Stomatology, Fourth Military Medical University</institution>, Xi’an, Shaanxi,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Orthopedics Surgery, Xijing Hospital, Fourth Military Medical University</institution>, Xi’an, Shaanxi,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Stomatology, PLA Xizang Military Region General Hospital</institution>, Lhasa, Tibet,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Wenjia" sort="Liu, Wenjia" uniqKey="Liu W" first="Wenjia" last="Liu">Wenjia Liu</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>State Key Laboratory of Military Stomatology, Centre for Tissue Engineering, School of Stomatology, Fourth Military Medical University</institution>, Xi’an, Shaanxi,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Yihan" sort="Liu, Yihan" uniqKey="Liu Y" first="Yihan" last="Liu">Yihan Liu</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>State Key Laboratory of Military Stomatology, Centre for Tissue Engineering, School of Stomatology, Fourth Military Medical University</institution>, Xi’an, Shaanxi,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Stomatology</institution>, PLA 301th Hospital, Beijing,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Xicong" sort="Zhao, Xicong" uniqKey="Zhao X" first="Xicong" last="Zhao">Xicong Zhao</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>State Key Laboratory of Military Stomatology, Centre for Tissue Engineering, School of Stomatology, Fourth Military Medical University</institution>, Xi’an, Shaanxi,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Hao" sort="Zhang, Hao" uniqKey="Zhang H" first="Hao" last="Zhang">Hao Zhang</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>State Key Laboratory of Military Stomatology, Centre for Tissue Engineering, School of Stomatology, Fourth Military Medical University</institution>, Xi’an, Shaanxi,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Luo, Zhuojing" sort="Luo, Zhuojing" uniqKey="Luo Z" first="Zhuojing" last="Luo">Zhuojing Luo</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Orthopedics Surgery, Xijing Hospital, Fourth Military Medical University</institution>, Xi’an, Shaanxi,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jin, Yan" sort="Jin, Yan" uniqKey="Jin Y" first="Yan" last="Jin">Yan Jin</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>State Key Laboratory of Military Stomatology, Centre for Tissue Engineering, School of Stomatology, Fourth Military Medical University</institution>, Xi’an, Shaanxi,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28053317</idno><idno type="pmc">5215380</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215380</idno><idno type="RBID">PMC:5215380</idno><idno type="doi">10.1038/srep40088</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000840</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000840</idno><idno type="wicri:Area/Pmc/Curation">000840</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000840</idno><idno type="wicri:Area/Pmc/Checkpoint">000174</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000174</idno><idno type="wicri:Area/Ncbi/Merge">006D31</idno><idno type="wicri:Area/Ncbi/Curation">006D31</idno><idno type="wicri:Area/Ncbi/Checkpoint">006D31</idno><idno type="wicri:Area/Main/Merge">000191</idno><idno type="wicri:Area/Main/Curation">000191</idno><idno type="wicri:Area/Main/Exploration">000191</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Jawbone microenvironment promotes periodontium regeneration by regulating the function of periodontal ligament stem cells</title><author><name sortKey="Zhu, Bin" sort="Zhu, Bin" uniqKey="Zhu B" first="Bin" last="Zhu">Bin Zhu</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>State Key Laboratory of Military Stomatology, Centre for Tissue Engineering, School of Stomatology, Fourth Military Medical University</institution>, Xi’an, Shaanxi,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Orthopedics Surgery, Xijing Hospital, Fourth Military Medical University</institution>, Xi’an, Shaanxi,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Stomatology, PLA Xizang Military Region General Hospital</institution>, Lhasa, Tibet,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Wenjia" sort="Liu, Wenjia" uniqKey="Liu W" first="Wenjia" last="Liu">Wenjia Liu</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>State Key Laboratory of Military Stomatology, Centre for Tissue Engineering, School of Stomatology, Fourth Military Medical University</institution>, Xi’an, Shaanxi,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Yihan" sort="Liu, Yihan" uniqKey="Liu Y" first="Yihan" last="Liu">Yihan Liu</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>State Key Laboratory of Military Stomatology, Centre for Tissue Engineering, School of Stomatology, Fourth Military Medical University</institution>, Xi’an, Shaanxi,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Stomatology</institution>, PLA 301th Hospital, Beijing,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Xicong" sort="Zhao, Xicong" uniqKey="Zhao X" first="Xicong" last="Zhao">Xicong Zhao</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>State Key Laboratory of Military Stomatology, Centre for Tissue Engineering, School of Stomatology, Fourth Military Medical University</institution>, Xi’an, Shaanxi,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Hao" sort="Zhang, Hao" uniqKey="Zhang H" first="Hao" last="Zhang">Hao Zhang</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>State Key Laboratory of Military Stomatology, Centre for Tissue Engineering, School of Stomatology, Fourth Military Medical University</institution>, Xi’an, Shaanxi,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Luo, Zhuojing" sort="Luo, Zhuojing" uniqKey="Luo Z" first="Zhuojing" last="Luo">Zhuojing Luo</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Orthopedics Surgery, Xijing Hospital, Fourth Military Medical University</institution>, Xi’an, Shaanxi,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jin, Yan" sort="Jin, Yan" uniqKey="Jin Y" first="Yan" last="Jin">Yan Jin</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>State Key Laboratory of Military Stomatology, Centre for Tissue Engineering, School of Stomatology, Fourth Military Medical University</institution>, Xi’an, Shaanxi,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>During tooth development, the jawbone interacts with dental germ and provides the development microenvironment. Jawbone-derived mesenchymal stem cells (JBMSCs) maintain this microenvironment for root and periodontium development. However, the effect of the jawbone microenvironment on periodontium tissue regeneration is largely elusive. Our previous study showed that cell aggregates (CAs) of bone marrow mesenchymal stem cells promoted periodontium regeneration on the treated dentin scaffold. Here, we found that JBMSCs enhanced not only the osteogenic differentiation of periodontal ligament stem cells (PDLSCs) but also their adhesion to titanium (Ti) material surface. Importantly, the compound CAs of PDLSCs and JBMSCs regenerated periodontal ligament-like fibers and mineralized matrix on the Ti scaffold surface, both in nude mice ectopic and minipig orthotopic transplantations. Our data revealed that an effective regenerative microenvironment, reconstructed by JBMSCs, promoted periodontium regeneration by regulating PDLSCs function on the Ti material.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Slavkin, H C" uniqKey="Slavkin H">H. C. Slavkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luan, X" uniqKey="Luan X">X. Luan</name></author><author><name sortKey="Ito, Y" uniqKey="Ito Y">Y. Ito</name></author><author><name sortKey="Diekwisch, T G" uniqKey="Diekwisch T">T. G. Diekwisch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thesleff, I" uniqKey="Thesleff I">I. Thesleff</name></author><author><name sortKey="Vaahtokari, A" uniqKey="Vaahtokari A">A. Vaahtokari</name></author><author><name sortKey="Kettunen, P" uniqKey="Kettunen P">P. Kettunen</name></author><author><name sortKey="Aberg, T" uniqKey="Aberg T">T. Aberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cobourne, M T" uniqKey="Cobourne M">M. T. Cobourne</name></author><author><name sortKey="Sharpe, P T" uniqKey="Sharpe P">P. T. Sharpe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Langer, R" uniqKey="Langer R">R. Langer</name></author><author><name sortKey="Vacanti, J P" uniqKey="Vacanti J">J. P. Vacanti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matsubara, T" uniqKey="Matsubara T">T. Matsubara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cicconetti, A" uniqKey="Cicconetti A">A. Cicconetti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mason, S" uniqKey="Mason S">S. Mason</name></author><author><name sortKey="Tarle, S A" uniqKey="Tarle S">S. A. Tarle</name></author><author><name sortKey="Osibin, W" uniqKey="Osibin W">W. Osibin</name></author><author><name sortKey="Kinfu, Y" uniqKey="Kinfu Y">Y. Kinfu</name></author><author><name sortKey="Kaigler, D" uniqKey="Kaigler D">D. Kaigler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Panagiotopoulou, O" uniqKey="Panagiotopoulou O">O. Panagiotopoulou</name></author><author><name sortKey="Kupczik, K" uniqKey="Kupczik K">K. Kupczik</name></author><author><name sortKey="Cobb, S N" uniqKey="Cobb S">S. N. Cobb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seo, B M" uniqKey="Seo B">B. M. Seo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iwata, T" uniqKey="Iwata T">T. Iwata</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, J" uniqKey="Zhou J">J. Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name></author><author><name sortKey="Rossi, F M" uniqKey="Rossi F">F. M. Rossi</name></author><author><name sortKey="Putnins, E E" uniqKey="Putnins E">E. E. Putnins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xie, H" uniqKey="Xie H">H. Xie</name></author><author><name sortKey="Liu, H" uniqKey="Liu H">H. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, B" uniqKey="Zhu B">B. Zhu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Messenger, M P" uniqKey="Messenger M">M. P. Messenger</name></author><author><name sortKey="Tomlins, P E" uniqKey="Tomlins P">P. E. Tomlins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meng, J" uniqKey="Meng J">J. Meng</name></author><author><name sortKey="Bencze, M" uniqKey="Bencze M">M. Bencze</name></author><author><name sortKey="Asfahani, R" uniqKey="Asfahani R">R. Asfahani</name></author><author><name sortKey="Muntoni, F" uniqKey="Muntoni F">F. Muntoni</name></author><author><name sortKey="Morgan, J E" uniqKey="Morgan J">J. E. Morgan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Atala, A" uniqKey="Atala A">A. Atala</name></author><author><name sortKey="Irvine, D J" uniqKey="Irvine D">D. J. Irvine</name></author><author><name sortKey="Moses, M" uniqKey="Moses M">M. Moses</name></author><author><name sortKey="Shaunak, S" uniqKey="Shaunak S">S. Shaunak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, W" uniqKey="Guo W">W. Guo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsumanuma, Y" uniqKey="Tsumanuma Y">Y. Tsumanuma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shi, S" uniqKey="Shi S">S. Shi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anselme, K" uniqKey="Anselme K">K. Anselme</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Y K" uniqKey="Wang Y">Y. K. Wang</name></author><author><name sortKey="Chen, C S" uniqKey="Chen C">C. S. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Teo, G S" uniqKey="Teo G">G. S. Teo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valcarcel, M" uniqKey="Valcarcel M">M. Valcarcel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walter, M N" uniqKey="Walter M">M. N. Walter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, S" uniqKey="Lee S">S. Lee</name></author><author><name sortKey="Choi, E" uniqKey="Choi E">E. Choi</name></author><author><name sortKey="Cha, M J" uniqKey="Cha M">M. J. Cha</name></author><author><name sortKey="Hwang, K C" uniqKey="Hwang K">K. C. Hwang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kilian, K A" uniqKey="Kilian K">K. A. Kilian</name></author><author><name sortKey="Bugarija, B" uniqKey="Bugarija B">B. Bugarija</name></author><author><name sortKey="Lahn, B T" uniqKey="Lahn B">B. T. Lahn</name></author><author><name sortKey="Mrksich, M" uniqKey="Mrksich M">M. Mrksich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peng, R" uniqKey="Peng R">R. Peng</name></author><author><name sortKey="Yao, X" uniqKey="Yao X">X. Yao</name></author><author><name sortKey="Ding, J" uniqKey="Ding J">J. Ding</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, B" uniqKey="Yang B">B. Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gurel Pekozer, G" uniqKey="Gurel Pekozer G">G. Gurel Pekozer</name></author><author><name sortKey="Torun Kose, G" uniqKey="Torun Kose G">G. Torun Kose</name></author><author><name sortKey="Hasirci, V" uniqKey="Hasirci V">V. Hasirci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="James, A W" uniqKey="James A">A. W. James</name></author><author><name sortKey="Levi, B" uniqKey="Levi B">B. Levi</name></author><author><name sortKey="Commons, G W" uniqKey="Commons G">G. W. Commons</name></author><author><name sortKey="Glotzbach, J" uniqKey="Glotzbach J">J. Glotzbach</name></author><author><name sortKey="Longaker, M T" uniqKey="Longaker M">M. T. Longaker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y. Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bai, Y" uniqKey="Bai Y">Y. Bai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stein, G S" uniqKey="Stein G">G. S. Stein</name></author><author><name sortKey="Lian, J B" uniqKey="Lian J">J. B. Lian</name></author><author><name sortKey="Owen, T A" uniqKey="Owen T">T. A. Owen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, S" uniqKey="Guo S">S. Guo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, F" uniqKey="Li F">F. Li</name></author><author><name sortKey="Redick, S D" uniqKey="Redick S">S. D. Redick</name></author><author><name sortKey="Erickson, H P" uniqKey="Erickson H">H. P. Erickson</name></author><author><name sortKey="Moy, V T" uniqKey="Moy V">V. T. Moy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miyamoto, S" uniqKey="Miyamoto S">S. Miyamoto</name></author><author><name sortKey="Katz, B Z" uniqKey="Katz B">B. Z. Katz</name></author><author><name sortKey="Lafrenie, R M" uniqKey="Lafrenie R">R. M. Lafrenie</name></author><author><name sortKey="Yamada, K M" uniqKey="Yamada K">K. M. Yamada</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hynes, R O" uniqKey="Hynes R">R. O. Hynes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kashima, T G" uniqKey="Kashima T">T. G. Kashima</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Han, P" uniqKey="Han P">P. Han</name></author><author><name sortKey="Ivanovski, S" uniqKey="Ivanovski S">S. Ivanovski</name></author><author><name sortKey="Crawford, R" uniqKey="Crawford R">R. Crawford</name></author><author><name sortKey="Xiao, Y" uniqKey="Xiao Y">Y. Xiao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, D C" uniqKey="Liu D">D. C. Liu</name></author><author><name sortKey="Yang, X N" uniqKey="Yang X">X. N. Yang</name></author><author><name sortKey="Huang, C Z" uniqKey="Huang C">C. Z. Huang</name></author><author><name sortKey="Sun, Y G" uniqKey="Sun Y">Y. G. Sun</name></author><author><name sortKey="Dai, X M" uniqKey="Dai X">X. M. Dai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, W" uniqKey="Zhou W">W. Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, Q" uniqKey="Zhou Q">Q. Zhou</name></author><author><name sortKey="Yang, P" uniqKey="Yang P">P. Yang</name></author><author><name sortKey="Li, X" uniqKey="Li X">X. Li</name></author><author><name sortKey="Liu, H" uniqKey="Liu H">H. Liu</name></author><author><name sortKey="Ge, S" uniqKey="Ge S">S. Ge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Michaels, C M" uniqKey="Michaels C">C. M. Michaels</name></author><author><name sortKey="Keller, J C" uniqKey="Keller J">J. C. Keller</name></author><author><name sortKey="Stanford, C M" uniqKey="Stanford C">C. M. Stanford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Besimo, C" uniqKey="Besimo C">C. Besimo</name></author><author><name sortKey="Graber, G" uniqKey="Graber G">G. Graber</name></author><author><name sortKey="Schaffner, T" uniqKey="Schaffner T">T. Schaffner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakao, K" uniqKey="Nakao K">K. Nakao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oshima, M" uniqKey="Oshima M">M. Oshima</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oshima, M" uniqKey="Oshima M">M. Oshima</name></author><author><name sortKey="Tsuji, T" uniqKey="Tsuji T">T. Tsuji</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ou, K L" uniqKey="Ou K">K. L. Ou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, B" uniqKey="Li B">B. Li</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhu, Bin" sort="Zhu, Bin" uniqKey="Zhu B" first="Bin" last="Zhu">Bin Zhu</name></noRegion><name sortKey="Jin, Yan" sort="Jin, Yan" uniqKey="Jin Y" first="Yan" last="Jin">Yan Jin</name><name sortKey="Liu, Wenjia" sort="Liu, Wenjia" uniqKey="Liu W" first="Wenjia" last="Liu">Wenjia Liu</name><name sortKey="Liu, Yihan" sort="Liu, Yihan" uniqKey="Liu Y" first="Yihan" last="Liu">Yihan Liu</name><name sortKey="Liu, Yihan" sort="Liu, Yihan" uniqKey="Liu Y" first="Yihan" last="Liu">Yihan Liu</name><name sortKey="Luo, Zhuojing" sort="Luo, Zhuojing" uniqKey="Luo Z" first="Zhuojing" last="Luo">Zhuojing Luo</name><name sortKey="Zhang, Hao" sort="Zhang, Hao" uniqKey="Zhang H" first="Hao" last="Zhang">Hao Zhang</name><name sortKey="Zhao, Xicong" sort="Zhao, Xicong" uniqKey="Zhao X" first="Xicong" last="Zhao">Xicong Zhao</name><name sortKey="Zhu, Bin" sort="Zhu, Bin" uniqKey="Zhu B" first="Bin" last="Zhu">Bin Zhu</name><name sortKey="Zhu, Bin" sort="Zhu, Bin" uniqKey="Zhu B" first="Bin" last="Zhu">Bin Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000191 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000191 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= EdenteV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:5215380
|texte= Jawbone microenvironment promotes periodontium regeneration by regulating the function of periodontal ligament stem cells
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28053317" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a EdenteV2
| This area was generated with Dilib version V0.6.32. |  |